Prenatal superior to postnatal myelomeningocele surgery

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Fetal surgery for myelomeningocele?

The possibility of surgical repair of fetal anomalies in utero has long tantalized obstetricians and pediatric surgeons, especially since the development of high-resolution real-time ultrasonography. The presumption has been that earlier in utero repair would provide superior outcomes for the offspring than would postnatal surgery. However, postnatal treatment is much simpler and is not traumat...

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Prenatal intervention for urinary obstruction and myelomeningocele.

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Prenatal programming of postnatal plasticity?

Evidence indicates that maternal prenatal distress predicts problematic health and behavioral outcomes in children as well as infant/child cortisol levels and negative emotionality as reviewed here. Evidence that these physiological and behavioral characteristics themselves moderate environmental effects on development in a "for better and for worse" manner consistent with Belsky's differential...

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Bladder Function After Fetal Surgery for Myelomeningocele.

BACKGROUND A substudy of the Management of Myelomeningocele Study evaluating urological outcomes was conducted. METHODS Pregnant women diagnosed with fetal myelomeningocele were randomly assigned to either prenatal or standard postnatal surgical repair. The substudy included patients randomly assigned after April 18, 2005. The primary outcome was defined in their children as death or the need...

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ژورنال

عنوان ژورنال: The Journal of Pediatrics

سال: 2018

ISSN: 0022-3476

DOI: 10.1016/j.jpeds.2018.04.060